Ministry of Health and Welfare 1 article published in JoVE Medicine Integration of Brain Tissue Saturation Monitoring in Cardiopulmonary Exercise Testing in Patients with Heart Failure Shu-Chun Huang1,2,3, Carl PC Chen1,3, Tieh-Cheng Fu4, Yu-Jen Chen1,5,6 1Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Linkou, 2Healthy Aging Research Center, Chang Gung University, 3School of Medicine, College of Medicine, Chang Gung University, 4Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Keelung, 5National Quemoy University, 6Kinmen Hospital, Ministry of Health and Welfare This protocol integrated near-infrared spectroscopy into conventional cardiopulmonary exercise testing to identify the involvement of the cerebral hemodynamic response in exercise intolerance in patients with heart failure.