Sex-Specific Glial Biomarkers in Alzheimer's Disease: A Transcriptome Analysis
1Chengdu University of Traditional Chinese Medicine, 2Chengdu Shuangliu Hospital of Traditional Chinese Medicine, 3Department of Automation,Tsinghua University, 4Affiliated Reproductive & Women-Children Hospital,Chengdu University of Traditional Chinese Medicine, 5Department of Neurology, Dalian Municipal Central Hospital,Central Hospital of Dalian University of Technology
Summary
这项研究分析了 33 名阿尔茨海默病 （AD） 患者的单核转录组，揭示了神经胶质细胞中的性别特异性 DEG。功能富集分析突出了突触、神经和激素相关通路。确定了关键基因，即NLGN4Y及其调控因子，并提出了性别特异性AD的潜在治疗候选药物。
