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Journal
Biochemie
Development of a Click-Based Assay for Screening HAT1 Enzyme Activity
Development of a Click-Based Assay for Screening HAT1 Enzyme Activity
January 26, 2024
用于测量组蛋白乙酰转移酶 1 乙酰化的乙酰基点击化学测定法
01:28 min
•
443 Views
单击“测定”以测量组蛋白乙酰转移酶 1 乙酰化
04:18 min
•
65 Views
Shreenidhi Rajkumar
1
,
Danielle Dixon
1
,
Andrew M. Lipchik
2
,
Joshua J. Gruber
1
1
Departments of Internal Medicine and the Green Center for Reproductive Biology Sciences
,
University of Texas Southwestern Medical Center
,
2
Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences
,
Wayne State University
Summary
快速准确的化学检测以筛选特定抑制剂是药物开发武器库中的重要工具。在这里，我们提出了一种可扩展的乙酰点击化学测定法来测量HAT1乙酰化活性的抑制。
Article
