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Un ensayo químico de acetil-clic para medir la acetilación de la acetil 1 de la histona acetiltransferasa 1

JoVE 杂志
生物化学

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JoVE 杂志生物化学

An Acetyl-Click Chemistry Assay to Measure Histone Acetyltransferase 1 Acetylation

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Un ensayo químico de acetil-clic para medir la acetilación de la acetil 1 de la histona acetiltransferasa 1

400 Views

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01:28 min

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January 26, 2024

DOI:

10.3791/66054-v

DOI:

10.3791/66054-v

•

01:28 min

January 26, 2024

•

9 Views

Shreenidhi Rajkumar, Danielle Dixon, Andrew M. Lipchik, Joshua J. Gruber

¹Departments of Internal Medicine and the Green Center for Reproductive Biology Sciences,University of Texas Southwestern Medical Center, ²Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences,Wayne State University

Tags

Acetyl-Click Chemistry Assay Histone Acetyltransferase 1 (HAT1)Acetyl Transferase Activity High Throughput Screening Small Molecule Inhibitors Peptide Substrate Enzymatic Assay Chromatin Synthesis Tumor Growth Cancer Treatment

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