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生物化学
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Development of a Click-Based Assay for Screening HAT1 Enzyme Activity
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En acetyl-klikk-kjemianalyse for å måle histonacetyltransferase 1-acetylering
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生物化学
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JoVE 杂志 生物化学
An Acetyl-Click Chemistry Assay to Measure Histone Acetyltransferase 1 Acetylation

En acetyl-klikk-kjemianalyse for å måle histonacetyltransferase 1-acetylering

400 Views

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01:28 min

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January 26, 2024

DOI:

10.3791/66054-v

DOI:
10.3791/66054-v

•

01:28 min
January 26, 2024

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9 Views
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1Departments of Internal Medicine and the Green Center for Reproductive Biology Sciences,University of Texas Southwestern Medical Center, 2Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences,Wayne State University

Tags

Acetyl-Click Chemistry AssayHistone Acetyltransferase 1 (HAT1)Acetyl Transferase ActivityHigh Throughput ScreeningSmall Molecule InhibitorsPeptide SubstrateEnzymatic AssayChromatin SynthesisTumor GrowthCancer Treatment

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Rajkumar, S., Dixon, D., Lipchik, A. M., Gruber, J. J. An Acetyl-Click Chemistry Assay to Measure Histone Acetyltransferase 1 Acetylation. J. Vis. Exp. (203), e66054, doi:10.3791/66054 (2024).

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