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Accelerating Macromolecular Structural Analysis Using Smart Leginon Autoscreen

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Author Spotlight: Enhancing Cryo-Electron Microscopy by Automated Data Collection and Analysis Techniques

JoVE 杂志
生物化学

This content is Free Access.

JoVE 杂志生物化学

Cryo-Electron Microscopy Screening Automation Across Multiple Grids Using Smart Leginon

Author Spotlight: Enhancing Cryo-Electron Microscopy by Automated Data Collection and Analysis Techniques

Accelerating Macromolecular Structural Analysis Using Smart Leginon Autoscreen

DOI:

10.3791/66007-v

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01:41 min

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December 01, 2023

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Anjelique Sawh-Gopal², Aygul Ishemgulova*¹, Eugene Y. D. Chua*¹, Mahira F. Aragon*¹, Joshua H. Mendez, Edward T. Eng, Alex J. Noble

¹Simons Electron Microscopy Center, New York Structural Biology Center, ²Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology

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Keywords: Cryo-electron Microscopy Screening Automation Smart Leginon Data Collection Data Analysis Machine Learning Particle Picking 3D Flexibility Analysis Model Building Grid Screening Sample Preparation CryoEM Workflow Structural Biology Macromolecular Protein Complexes Grid Optimization

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