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Rekonstruktion der Blut-Hirn-Schranke in vitro zur Modellierung und therapeutischen Behandlung neurologischer Erkrankungen

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神经科学

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JoVE 杂志神经科学

Reconstruction of the Blood-Brain Barrier In Vitro to Model and Therapeutically Target Neurological Disease

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Rekonstruktion der Blut-Hirn-Schranke in vitro zur Modellierung und therapeutischen Behandlung neurologischer Erkrankungen

1,065 Views

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02:09 min

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October 20, 2023

DOI:

10.3791/65921-v

DOI:

10.3791/65921-v

•

02:09 min

October 20, 2023

•

9 Views

Camille Goldman*^1,2,3,4,5, Natalie Suhy*^1,2,3,4,5, Jessica E. Schwarz^2,3,4,5, Emily Ruth Sartori^2,3,4,5, Rikki B. Rooklin^2,3,4,5, Braxton R. Schuldt^2,3,4,5, Louise A. Mesentier-Louro^2,3,4,5, Joel W. Blanchard^2,3,4,5

¹Icahn School of Medicine at Mount Sinai, ²Black Family Stem Cell Institute at Mount Sinai, ³Ronald M. Loeb Center for Alzheimer’s Disease at Mount Sinai, ⁴Friedman Brain Institute at Mount Sinai, ⁵Nash Family Department of Neuroscience at Mount Sinai

Tags

Blood-brain Barrier In Vitro Model Alzheimer’s Disease Neurodegeneration Cerebrovascular Pathology APOE4 Amyloid Induced Pluripotent Stem Cells Personalized Therapy Drug Screening 3D Model BBB Function Cerebral Amyloid Angiopathy

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