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Crystallization of ABC Transporter Membrane Proteins in Lipidic Bicelles

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Author Spotlight: A Bicelle Crystallization Setup for ABC Transporter Membrane Proteins to Advance Drug Development

JoVE 杂志
生物化学

This content is Free Access.

JoVE 杂志生物化学

ABCG5/G8 Crystallization in a Lipidic Bicelle Environment for X-Ray Crystallography

Author Spotlight: A Bicelle Crystallization Setup for ABC Transporter Membrane Proteins to Advance Drug Development

Crystallization of ABC Transporter Membrane Proteins in Lipidic Bicelles

DOI:

10.3791/65828-v

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01:55 min

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August 25, 2023

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Sarah Wazir, Danny Farhat, Mahalashmi Srinivasan², Jyh-Yeuan Lee

¹Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine,University of Ottawa, ²Department of Biochemistry, Faculty of Medicine and Dentistry,University of Alberta

Tags

ABCG5/G8 Membrane Protein ATP-binding Cassette Transporter X-ray Crystallography Lipidic Bicelle Structural Studies Drug Discovery Lipid Recognition Lipid Translocation Membrane Protein Structure Detergent Phospholipid Bicelle

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