Journal
/
生物化学
/
Characterization of Ternary Complex Formation in PROTACs Using Biophysical Assays
/
The Development and Application of Biophysical Assays for Evaluating Ternary Complex Formation Induced by Proteolysis Targeting Chimeras (PROTACS)
JoVE 杂志
生物化学
需要订阅 JoVE 才能查看此.  登录或开始免费试用。
JoVE 杂志 生物化学
The Development and Application of Biophysical Assays for Evaluating Ternary Complex Formation Induced by Proteolysis Targeting Chimeras (PROTACS)
Please note that all translations are automatically generated. Click here for the English version.

The Development and Application of Biophysical Assays for Evaluating Ternary Complex Formation Induced by Proteolysis Targeting Chimeras (PROTACS)

Characterization of Ternary Complex Formation in PROTACs Using Biophysical Assays

DOI:
10.3791/65718-v

•

01:09 min

•

January 12, 2024

•

,
1Center for the Development of Therapeutics,The Broad Institute of MIT and Harvard

Tags

Biophysical AssaysTernary Complex FormationProteolysis Targeting Chimeras (PROTACs)Surface Plasmon Resonance (SPR)Biolayer Interferometry (BLI)Isothermal Titration Calorimetry (ITC)Brd4BD2VHLPPM1DCereblon (CRBN)KineticsThermodynamicsCooperativityHook Effect

Embed

添加到播放列表

Usage Statistics

Related Videos

check_url/cn/65718?article_type=v

The Development and Application of Biophysical Assays for Evaluating Ternary Complex Formation Induced by Proteolysis Targeting Chimeras (PROTACS)
check_url/cn/65718?article_type=v

Isothermal Titration Calorimetry for Evaluating PROTACS-Induced Ternary Complex Formation
check_url/cn/65718?article_type=v

Biolayer Interferometry (BLI) for Evaluating PROTACS-Induced Ternary Complex Formation
check_url/cn/65718?article_type=v

Surface Plasmon Resonance (SPR) for Evaluating PROTACS-Induced Ternary Complex Formation

Read Article