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Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products
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化学
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JoVE 杂志 化学
Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products

Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products

10,596 Views

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11:13 min

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March 12, 2020

DOI:

10.3791/60825-v

DOI:
10.3791/60825-v

•

11:13 min
March 12, 2020

•

14 Views
, , ,
1Department of Organic Chemistry, Institute of Chemistry,University of Campinas (UNICAMP), 2Center for Natural and Human Sciences,Federal University of ABC (UFABC)

Summary

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A mass spectrometry-guided genome mining protocol is established and described here. It is based on genome sequence information and LC-MS/MS analysis and aims to facilitate identification of molecules from complex microbial and plant extracts.

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Mass SpectrometryGenome MiningNatural Product DiscoveryMolecular NetworkingWhole Genome SequencingGenotype-to-chemotypeBiosynthetic ClustersSecondary MetabolismGNPSStreptomycesFungiPlants

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Sigrist, R., Paulo, B. S., Angolini, C. F. F., De Oliveira, L. G. Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products. J. Vis. Exp. (157), e60825, doi:10.3791/60825 (2020).

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