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Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats
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神经科学
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JoVE 杂志 神经科学
Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats

Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats

DOI:
10.3791/58423-v

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06:39 min

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October 17, 2018

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, , , ,
1Department of Neurology,Second Hospital of Shanxi Medical University, 2Department of Neurology,PLA Army General Hospital, 3Department of Neurology,NO 261 Hospital of PLA

Chapters

  • 00:04Title
  • 00:56LPS Injection
  • 01:45Evan s Blue Injection
  • 02:29Fixation of Tissue
  • 03:15Evan s Blue Double Staining
  • 03:50H&E Staining
  • 05:18Results: Detection of Sub-acute Cerebral Microhemorrhages
  • 05:47Conclusion

Summary

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We present a protocol to induce and detect CMHs caused by LPS injection in Sprague-Dawley rats, which may be utilized in future research investigations on the pathogenesis of CMHs.

Tags

Cerebral MicrohemorrhagesLipopolysaccharide (LPS) InjectionInflammationBrain DisordersSprague Dawley RatsEvans BlueBlood-brain BarrierCardiac PerfusionParaformaldehydeCryostatDAPI

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