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在成年小鼠中的亚型腺相关病毒9（AAV9）载体递送

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神经科学

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JoVE 杂志神经科学

Subpial Adeno-associated Virus 9 (AAV9) Vector Delivery in Adult Mice

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在成年小鼠中的亚型腺相关病毒9（AAV9）载体递送

16,938 Views

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08:32 min

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July 13, 2017

DOI:

10.3791/55770-v

DOI:

10.3791/55770-v

•

08:32 min

July 13, 2017

•

19 Views

Takahiro Tadokoro¹, Atsushi Miyanohara¹, Michael Navarro¹, Kota Kamizato¹, Stefan Juhas², Jana Juhasova², Silvia Marsala¹, Oleksandr Platoshyn¹, Erik Curtis³, Brandon Gabel³, Joseph Ciacci³, Nada Lukacova⁴, Katarina Bimbova⁴, Martin Marsala^1,4

¹Neuroregeneration Laboratory, Department of Anesthesiology,University of California, San Diego, ²Institute of Animal Physiology and Genetics,Czech Academy of Sciences, ³Department of Neurosurgery,University of California, San Diego, ⁴Institute of Neurobiology,Slovak Academy of Sciences

Summary

本研究的目的是通过在成年小鼠中使用新的唾液基因传递技术来开发和验证脊髓腺相关病毒9（AAV9）介导的基因递送的效力和安全性。

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