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A Novel Method to Model Chronic Traumatic Encephalopathy in Drosophila
Chapters
- 00:05Title
- 01:01Assembly of the Strike Device
- 03:13Operation of the Strike Device
- 05:24Video-assisted Movement Tracking
- 07:19Results: Long-term Function and Survivorship After a Mild Traumatic Brain Injury (mTBI) Protocol Using the Chronic Traumatic Eencephalopathy (CTE) Model
- 09:34Conclusion
Here, we describe a new approach to inflict closed-head traumatic brain injury in Drosophila melanogaster. Our method has the advantage of directly delivering repetitive impacts with adjustable strength to the head alone. Further exploration of the invertebrate system will help to illuminate the pathogenesis of chronic traumatic encephalopathy.
