The development of new refinement strategies for laboratory mice is a challenging task that contributes towards fulfilling the 3R principle. This protocol introduces clicker training as a cognitive enrichment program for laboratory mice.
Leidinger, C., Herrmann, F., Thöne-Reineke, C., Baumgart, N., Baumgart, J. Introducing Clicker Training as a Cognitive Enrichment for Laboratory Mice. J. Vis. Exp. (121), e55415, doi:10.3791/55415 (2017).