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免疫与感染
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JoVE 杂志 免疫与感染
Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
DOI:

10:10 min

November 08, 2016

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Chapters

  • 00:05Title
  • 00:43In Vitro Antigen-specific Inducible Pluripotent Stem Cell (iPSC)-T Regulatory Cell (T-reg) Differentiation
  • 04:00In Vivo iPSC Maturation and Autoimmune Arthritis Suppression and Analysis
  • 06:24Results: Representative Antigen-specific iPSC-T-reg Mediated Arthritis Suppression
  • 08:54Conclusion

Summary

自动翻译

We present here a method to develop functional antigen (Ag)-specific regulatory T cells (Tregs) from induced pluripotent stem cells (iPSCs) for immunotherapy of autoimmune arthritis in a murine model.

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