Desenvolvimento de um modelo de fígado fibrótica induzida por etanol no peixe-zebra para estudar Progenitor mediada por células de regeneração de hepatócitos

Sustained fibrosis with deposition of excessive extracellular matrix proteins leads to cirrhosis. Alcohol abuse is one of the main causes of severe liver disease. We established an ethanol-induced zebrafish fibrotic liver model to study the mechanisms and strategies of promoting hepatocyte regeneration upon alcohol-induced injury.