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Intracerebroventriculaire Injectie van amyloid-β peptiden in normale muizen om acuut induceren Alzheimer-achtige cognitieve tekorten
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Intracerebroventricular Injection of Amyloid-β Peptides in Normal Mice to Acutely Induce Alzheimer-like Cognitive Deficits
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Intracerebroventriculaire Injectie van amyloid-β peptiden in normale muizen om acuut induceren Alzheimer-achtige cognitieve tekorten

40,324 Views

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08:01 min

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March 16, 2016

DOI:

10.3791/53308-v

DOI:
10.3791/53308-v

•

08:01 min
March 16, 2016

•

79 Views
, , , ,
1Center for Neuro-Medicine,Korea Institute of Science and Technology, 2Research Institute,GoshenBiotech, Inc., 3Department of Chemical and Biological Engineering,Princeton University, 4Biological Chemistry Program,Korea University of Science and Technology

Summary

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De amyloid-β (Aß) -injected diermodel kan de toediening van een bepaalde hoeveelheid en de soort van Ap-fragmenten en vermindert de individuele verschillen binnen elke studiegroep. Dit protocol beschrijft de intracerebroventriculaire (ICV) injectie van Ap zonder stereotactische instrumenten, waardoor de productie van Alzheimer-achtige gedragsafwijkingen bij normale muizen.

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Kim, H. Y., Lee, D. K., Chung, B., Kim, H. V., Kim, Y. Intracerebroventricular Injection of Amyloid-β Peptides in Normal Mice to Acutely Induce Alzheimer-like Cognitive Deficits. J. Vis. Exp. (109), e53308, doi:10.3791/53308 (2016).

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