需要订阅 JoVE 才能查看此. 登录或开始免费试用。
Optogenetic Stimulation of the Auditory Nerve
1InnerEarLab, Department of Otolaryngology,University Medical Center Goettingen, 2Bernstein Focus for Neurotechnology,University of Goettingen, 3Auditory Systems Physiology Group, Department of Otolaryngology,University Medical Center Goettingen, 4Center for Nanoscale Microscopy and Molecular Physiology of the Brain,University of Goettingen, 5Department of Chemical, Electronic, and Biomedical Engineering,University of Guanajuato
Chapters
- 00:05Title
- 01:54Preparing the μLED Stimulator
- 03:31Cochleostomy for Transcochlear Stimulation
- 05:12Implanting the Stimulator and Recording Optogenetic Auditory Brainstem Responses (oABR)
- 07:40Recording Optically Evoked Local Field Potentials
- 08:21Results: Comapring Auditory Brainstem Response and Signal Propagation from oABR
- 09:46Conclusion
Cochlear implants (CIs) enable hearing by direct electrical stimulation of the auditory nerve. However, poor frequency and intensity resolution limits the quality of hearing with CIs. Here we describe optogenetic stimulation of the auditory nerve in mice as an alternative strategy for auditory research and developing future CIs.
