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Quantitative and Qualitative Examination of Particle-particle Interactions Using Colloidal Probe Nanoscopy
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化学
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JoVE 杂志 化学
Quantitative and Qualitative Examination of Particle-particle Interactions Using Colloidal Probe Nanoscopy

Quantitative and Qualitative Examination of Particle-particle Interactions Using Colloidal Probe Nanoscopy

DOI:
10.3791/51874-v

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13:15 min

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July 18, 2014

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, , ,
1Faculty of Pharmacy,University of Sydney, 2Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine,Dankook University

Chapters

  • 00:05Title
  • 02:09Preparing the Colloidal Probe and Atomic Force Microscope Substrate
  • 04:45Mounting the Colloidal Probe, Aligning the Laser, and Equilibrating the System
  • 07:25Imaging, Data Acquisition, and Preparation for Analysis
  • 11:19Results: Interactions Between Lipid-based Particles and Model Pressurized Metered Dose Inhaler Propellant
  • 12:51Conclusion

Summary

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Colloidal probe nanoscopy can be used within a variety of fields to gain insight into the physical stability and coagulation kinetics of colloidal systems and aid in drug discovery and formulation sciences using biological systems. The method described within provides a quantitative and qualitative means to study such systems.

Tags

Colloidal Probe NanoscopyAtomic Force MicroscopeParticle-particle InteractionsAdhesive PropertiesBinding EnergiesPhysical StabilityCoagulation KineticsColloidal SystemsEmulsionsFoamsSuspensionsPharmaceuticalsFoodsPaintsPaperSoilMineralsDetergentsPrintingDrug DiscoveryFormulation Development

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