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Fluido laterale Percussioni: Modello delle lesioni cerebrali traumatiche nei topi
1Department of Neuroscience and Cell Biology,University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 2Spinal Cord and Brain Injury Research Center, 3Department of Anatomy and Neurobiology, Department of Physical Medicine and Rehabilitation,University of Kentucky Chandler Medical Center
Chapters
- 00:05Title
- 01:23Craniectomy
- 05:46Induction of Injury
- 08:19Cognitive, Motor and Histological Outcomes
Laterale fluido percussioni (LFP), un modello stabilito di lesioni cerebrali traumatiche nei topi, è dimostrato. LFP soddisfa tre criteri principali per i modelli animali: rilevanza validità, l'affidabilità e la clinica. La procedura, che consiste di craniotomia chirurgica, la fissazione del mozzo seguita da induzione di lesioni, con conseguente lesioni focali e diffuse, è descritto.
Tags
Lateral Fluid PercussionTraumatic Brain InjuryTBI ResearchHead InjuriesMorbidityMortalityPrimary InjurySecondary ConsequencesRegenerative ProcessesContusionSkull FractureShearingStretchingDisplacement Of BrainHematomasLacerationsVascular ResponseWhite Matter DamageDiffuse Axonal InjuryEdemaIncreased Intracranial PressureMicroscopic AlterationsExcitotoxic NeurotransmittersImmune MediatorsOxygen RadicalsLong-term Neurological DisabilitiesAnimal Models Of TBICellular EventsMolecular Events
