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An In Vitro System to Study Tumor Dormancy and the Switch to Metastatic Growth
JoVE 杂志
医学
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JoVE 杂志 医学
An In Vitro System to Study Tumor Dormancy and the Switch to Metastatic Growth

An In Vitro System to Study Tumor Dormancy and the Switch to Metastatic Growth

DOI:
10.3791/2914-v

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09:14 min

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August 11, 2011

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1Department of Biology,University of Haifa, 2Transgenic Oncogenesis and Genomics Section, Laboratory of Cancer Biology and Genetics,National Cancer Institute

Chapters

  • 00:05Title
  • 01:41Cell Proliferation Assay of Dormant (Quiescent) and Metastatic (Proliferating) Tumor Cells Cultured in a 3D-Basement Membrane Extract (BME) System
  • 04:14Immunofluorescent Staining for Cell Signaling Molecules in Dormant (Quiescent) Tumor Cells and/or Metastatic (Proliferating) Tumor Cells
  • 07:17Evaluation of Tumor Cell Proliferation and Dormancy Using the 3D-BME Culture System
  • 08:55Conclusion

Summary

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A modified 3-D in vitro system is presented in which growth characteristics of several tumor cell lines in reconstituted basement membrane correlate with the dormant or proliferative behavior of the tumor cells at a metastatic secondary site in vivo.

Tags

In Vitro SystemTumor DormancyMetastatic GrowthBreast Cancer RecurrenceLatent PeriodMetastatic SitesConventional TherapiesDormant Cancer CellsQuiescent Solitary CellsDisease ProgressionBone MarrowBloodLymph NodesMechanisms Regulating DormancyProliferative StateModel SystemsMetastatic Progression

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