Chapter 7
Structure and Organization of DNA
![DNA as a Genetic Template](https://jovecdn2.ccindex.cn/files/media/science-education/science-education-thumbs/11527.jpg)
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature.…
![Structure of a Gene](https://jovecdn2.ccindex.cn/files/media/science-education/science-education-thumbs/13181.jpg)
A gene is the fundamental unit of heredity. Every individual has two copies of each gene, one inherited from each parent. Although most people…
![The Nucleosome](https://jovecdn2.ccindex.cn/files/media/science-education/science-education-thumbs/11531.jpg)
DNA in a human cell is almost 2m long and it is packed inside a tiny nucleus that is only a few microns in diameter. The level of compaction of DNA…
![Chromatin Packaging](https://jovecdn2.ccindex.cn/files/media/science-education/science-education-thumbs/11534.jpg)
Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a…
![Heterochromatin](https://jovecdn2.ccindex.cn/files/media/science-education/science-education-thumbs/12222.jpg)
The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted…
![Histone Modification](https://jovecdn2.ccindex.cn/files/media/science-education/science-education-thumbs/11537.jpg)
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational…
![Site Specific Lysine Acetylation of Histones for Nucleosome Reconstitution using Genetic Code Expansion in <em>Escherichia coli</em>](https://jovecdn2.ccindex.cn/files/thumbs/62113_t.png)
Acetylated histone proteins can be easily expressed in Escherichia coli encoding a mutant, Nε-acetyl-lysine (AcK)-specific Methanosarcina mazi…
![CRISPR-Mediated Reorganization of Chromatin Loop Structure](https://jovecdn2.ccindex.cn/files/thumbs/57457_t.png)
CRISPR-Mediated Reorganization of Chromatin Loop Structure
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Recent studies have clearly shown that long-range, three-dimensional chromatin looping interactions play a significant role in the regulation of gene…