Selective Gene Silencing in the Choroid Plexus

Selective Gene Silencing in the Choroid Plexus

June 16, 2023

Gerichte uitschakeling van genen in de plexus choroideus

ChP-specifieke knockdown van A_2ARs met AAV2/5-shRNA en Cre/LoxP-systeem

Yuwen Yang*¹, Chenxing Qi*¹, Lanxin Hu¹, Cheng Zheng¹, Xuhang Li¹, Wu Zheng¹, Yiyun Weng², Haiyan Lin^3,4

¹State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital,Wenzhou Medical University, ²Department of Neurology,the First Affiliated Hospital of Wenzhou Medical University, ³Rehabilitation Medicine Center,The Second Affiliated Hospital of Wenzhou Medical University, ⁴Integrative & Optimized Medicine Research Center, China-USA Institute for Acupuncture and Rehabilitation,Wenzhou Medical University

Summary

Hier beschrijven we een methode om selectief genexpressies in de plexus choroideus te veranderen en tegelijkertijd impact in andere hersengebieden te vermijden.

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