Using the MouseWalker to Quantify Locomotor Dysfunction in a Mouse Model of Spinal Cord Injury

Ana Filipa Isidro; Alexandra M. Medeiros; Isaura Martins; Dalila Neves-Silva; Leonor Sa&#250;de; C&#233;sar S. Mendes

doi:10.3791/65207

Journal

神经科学

Quantifying Locomotor Dysfunction in Spinal Cord Injury Mice Using MouseWalker

March 24, 2023

Author Spotlight: Using the MouseWalker to Quantify Locomotor Dysfunction in a Mouse Model of Spinal Cord Injury

02:40 min

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1,572 Views

Setting Up of the MouseWalker (MW) Apparatus

01:08 min

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209 Views

Video Acquisition and Preparing the Videos for the MouseWalker (MW) Tracking Software

01:10 min

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199 Views

MouseWalker (MW) Video Tracking and Kinematic Data Analysis

03:07 min

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176 Views

Ana Filipa Isidro¹, Alexandra M. Medeiros², Isaura Martins¹, Dalila Neves-Silva¹, Leonor Saúde^1,3, César S. Mendes²

¹Instituto de Medicina Molecular João Lobo Antunes,Faculdade de Medicina da Universidade de Lisboa, ²iNOVA4Health, NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM,Universidade Nova de Lisboa, ³Instituto de Histologia e Biologia do Desenvolvimento,Faculdade de Medicina da Universidade de Lisboa

Summary

An experimental pipeline to quantitatively describe the locomotor pattern of freely walking mice using the MouseWalker (MW) toolbox is provided, ranging from initial video recordings and tracking to post-quantification analysis. A spinal cord contusion injury model in mice is employed to demonstrate the usefulness of the MW system.