Gordon J. Lithgow Buck Institute for Research on Aging Biography Publications Institution JoVE Articles Gordon J. Lithgow has not added a biography. If you are Gordon J. Lithgow and would like to personalize this page please email our Author Liaison for assistance. Publications Dysregulated Iron Metabolism in C. Elegans Catp-6/ATP13A2 Mutant Impairs Mitochondrial Function Neurobiology of Disease. 06, 2020 | Pubmed ID: 32032734 Intervention Testing Program: the Creatine Analog β-guanidinopropionic Acid Does Not Extend Lifespan in Nematodes MicroPublication Biology. 2020 | Pubmed ID: 31998863 Intervention Testing Program: the Tyrosine Kinase Inhibitor Imatinib Mesylate Does Not Extend Lifespan in Nematodes MicroPublication Biology. 2019 | Pubmed ID: 32010883 Automated Lifespan Determination Across Caenorhabditis Strains and Species Reveals Assay-specific Effects of Chemical Interventions GeroScience. 12, 2019 | Pubmed ID: 31820364 From Discoveries in Ageing Research to Therapeutics for Healthy Ageing Nature. 07, 2019 | Pubmed ID: 31292558 Drugs That Target Aging: How Do We Discover Them? Expert Opinion on Drug Discovery. 06, 2019 | Pubmed ID: 30973028 Acarbose Improves Health and Lifespan in Aging HET3 Mice Aging Cell. 04, 2019 | Pubmed ID: 30688027 Natural Genetic Variation in Yeast Reveals That NEDD4 Is a Conserved Modifier of Mutant Polyglutamine Aggregation G3 (Bethesda, Md.). 11, 2018 | Pubmed ID: 30194090 A Long Journey to Reproducible Results Nature. 08, 2017 | Pubmed ID: 28836615 Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson's Disease Mediators of Inflammation. 2017 | Pubmed ID: 28473732 Impact of Genetic Background and Experimental Reproducibility on Identifying Chemical Compounds with Robust Longevity Effects Nature Communications. Feb, 2017 | Pubmed ID: 28220799 Vitamin D Promotes Protein Homeostasis and Longevity Via the Stress Response Pathway Genes Skn-1, Ire-1, and Xbp-1 Cell Reports. 10, 2016 | Pubmed ID: 27783938 A Caenorhabditis Elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive α-Dicarbonyl Detoxification Current Biology : CB. Nov, 2016 | Pubmed ID: 27773573 Chemical Activation of a Food Deprivation Signal Extends Lifespan Aging Cell. 10, 2016 | Pubmed ID: 27220516 Zinc Levels Modulate Lifespan Through Multiple Longevity Pathways in Caenorhabditis Elegans PloS One. 2016 | Pubmed ID: 27078872 Long Live FOXO: Unraveling the Role of FOXO Proteins in Aging and Longevity Aging Cell. Apr, 2016 | Pubmed ID: 26643314 Mitochondrial Quality Control Via the PGC1α-TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2015 | Pubmed ID: 26377470 Iron Promotes Protein Insolubility and Aging in C. Elegans Aging. Nov, 2014 | Pubmed ID: 25554795 Geroscience: Linking Aging to Chronic Disease Cell. Nov, 2014 | Pubmed ID: 25417146 Manganese Disturbs Metal and Protein Homeostasis in Caenorhabditis Elegans Metallomics : Integrated Biometal Science. Oct, 2014 | Pubmed ID: 25057947 Stress Biology and Aging Mechanisms: Toward Understanding the Deep Connection Between Adaptation to Stress and Longevity The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Jun, 2014 | Pubmed ID: 24833580 A DNA Synthesis Inhibitor is Protective Against Proteotoxic Stressors Via Modulation of Fertility Pathways in Caenorhabditis Elegans Aging. Oct, 2013 | Pubmed ID: 24123581 Age-related Micro-RNA Abundance in Individual C. Elegans Aging. Jun, 2013 | Pubmed ID: 23793570 Dimethyl Sulfoxide and Dimethyl Formamide Increase Lifespan of C. Elegans in Liquid Mechanisms of Ageing and Development. Mar, 2013 | Pubmed ID: 23313473 Curcumin and Neurodegenerative Diseases BioFactors (Oxford, England). Jan-Feb, 2013 | Pubmed ID: 23303664 Pharmacological Lifespan Extension of Invertebrates Ageing Research Reviews. Jan, 2013 | Pubmed ID: 22771382 Anti-inflammatory Role of the Isoflavone Diadzein in Lipopolysaccharide-stimulated Microglia: Implications for Parkinson's Disease Neurotoxicity Research. Feb, 2013 | Pubmed ID: 22573480 Translating Longevity Research into Healthspan Longevity & Healthspan. 2012 | Pubmed ID: 24764507 Tor1 Regulates Protein Solubility in Saccharomyces Cerevisiae Molecular Biology of the Cell. Dec, 2012 | Pubmed ID: 23097491 Aluminium Exposure Disrupts Elemental Homeostasis in Caenorhabditis Elegans Metallomics : Integrated Biometal Science. May, 2012 | Pubmed ID: 22534883 Pharmacological Maintenance of Protein Homeostasis Could Postpone Age-related Disease Aging Cell. Apr, 2012 | Pubmed ID: 22226190 Proteomic Analysis of Age-dependent Changes in Protein Solubility Identifies Genes That Modulate Lifespan Aging Cell. Feb, 2012 | Pubmed ID: 22103665 Life Span Extension Via EIF4G Inhibition is Mediated by Posttranscriptional Remodeling of Stress Response Gene Expression in C. Elegans Cell Metabolism. Jul, 2011 | Pubmed ID: 21723504 N-acylethanolamine Signalling Mediates the Effect of Diet on Lifespan in Caenorhabditis Elegans Nature. May, 2011 | Pubmed ID: 21562563 A New Look at Old Compounds Aging. Apr, 2011 | Pubmed ID: 21512207 Amyloid-binding Compounds Maintain Protein Homeostasis During Ageing and Extend Lifespan Nature. Apr, 2011 | Pubmed ID: 21451522 Why Aging Isn't Regulated: a Lamentation on the Use of Language in Aging Literature Experimental Gerontology. Oct, 2006 | Pubmed ID: 16959457 Does Anti-aging Equal Anti-microbial? Science of Aging Knowledge Environment : SAGE KE. Jun, 2003 | Pubmed ID: 12844540 Stress Resistance As a Determinate of C. Elegans Lifespan Mechanisms of Ageing and Development. Apr, 2002 | Pubmed ID: 11869734 Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow Xueshu Xie*1, Manish Chamoli*1, Dipa Bhaumik1, Renuka Sivapatham1, Suzanne Angeli1, Julie K. Andersen1, Gordon J. Lithgow1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 61366 生物学
Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow Xueshu Xie*1, Manish Chamoli*1, Dipa Bhaumik1, Renuka Sivapatham1, Suzanne Angeli1, Julie K. Andersen1, Gordon J. Lithgow1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 61366 生物学